Lu-177 PRRT Kidney BED Tracker
Cumulative renal biologically-effective dose across PRRT cycles, with the tolerance thresholds and remaining headroom
Kidney biologically effective dose (BED) is the accepted way to track cumulative renal risk across PRRT cycles, because it accounts for dose rate and sublethal-damage repair rather than absorbed dose alone. For each administration, BED = D · [1 + (D / (α/β)) · λ/(μ+λ)], with kidney α/β ≈ 2.6 Gy, repair half-time ≈ 2.8 h, and λ from the kidney effective half-life; cycle BEDs are additive. Widely used tolerance thresholds are ~40 Gy BED without renal risk factors and ~28 Gy with them (hypertension, diabetes), against the classic 23 Gy absorbed-dose TD₅/₅. Enter each cycle's kidney absorbed dose to track cumulative BED and remaining headroom.