Y-90 Radioembolization Activity Calculator
Prescribed activity by MIRD (glass), BSA (resin), or the partition model, with a lung-dose safety check
High-yield mode — key points, high-yield facts, tables & quizzes only. Toggle off for full text.
Three established methods prescribe Y-90 activity: the MIRD single-compartment method (glass microspheres), the BSA method (resin microspheres), and the partition model, which resolves tumour, normal-liver, and lung doses separately. All rest on the Y-90 constant of ~50 Gy·kg/GBq (49.4 Gy per GBq per kg of tissue if fully retained). Choose a method; the calculator returns the activity (GBq and mCi) and checks the lung dose against the 30 Gy single-administration limit (50 Gy cumulative).
Y-90 radioembolization — prescribed activity
All methods use the Y-90 constant 50 Gy·kg/GBq. Glass/MIRD: A = D × m / [50 × (1−LSF)]. Resin/BSA: A = (BSA − 0.2) + Vtumour/(Vtumour+Vliver). Partition: tumour, normal-liver, and lung doses from T/N and masses. Lung dose = 50 × A × LSF / mlung; keep ≤ 30 Gy per administration (≤ 50 Gy cumulative). Residual/reflux and non-target deposition are not modelled. Educational estimate — confirm every prescription with medical physics and your institutional protocol.